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She has over 20 years of experience using statistics and modeling approaches to associate survey data and laboratory measures from basic, clinical, and epidemiology investigations with a wide variety of health outcomes.


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An overarching goal of Dr. Pathmasiri develops and applies metabolomics to reveal metabolic pathway perturbations associated with disease states, therapeutic treatments, and environmentally relevant exposures. He has contributed to research in the areas of cancer, childhood obesity, early-life exposure to antibiotics, environmental exposure, kidney disease, osteoarthritis, rare diseases, and toxicology. He is well versed in using analytical instrumentation to study metabolic products of exogenous small molecule agents and their biological effects.

Stewart has over 10 years of experience using genomics, metabolomics and high-throughput molecular bioassays to investigate mechanisms involved in cancer and inflammation.

Abstracting and Indexing

She uses both in vitro and in vivo model systems of genetic diversity to gain insights into health disparities associated with cancer endpoints. Susan Sumner, PhD. Publications Effect of endotoxin and alum adjuvant vaccine on peanut allergy. Metabolomics reveal physiological changes in mayfly larvae Neocloeon triangulifer at ecological upper thermal limits. Preterm neonatal urinary renal developmental and acute kidney injury metabolomic profiling: an exploratory study Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine.

Herzog and K. Bainbridge amongst others incorporated many developments in vacuum technologies and electronics for power supplies and ion detection. Their work significantly improved magnetic focusing instruments leading to better performance, convenience and lower costs. Double-focusing machines, attaining greater precision by adding an electrostatic analyzer, were also greatly refined.

These instruments were built for the purpose of accurately determining the exact atomic weights of the elements and their isotopes; they made use of Faraday cups to convert particle impacts into an electric current for signal recording. Tremendous progress has been made since this pioneering work in, for example, ion generation, ion transmission, ion detection, signal amplification and, last but not least, computing technologies to control the instrument and record the data. Even the detailed analysis of genetic and genomic material is now being addressed by mass spectrometry.

The performance of mass spectrometers in combination with ionization techniques can be defined by several intrinsic parameters, i. The mass accuracy is described by the ratio between the mass error difference between measured and real mass and the theoretical mass, often represented as parts per million ppm , e. The sensitivity is described by the ratio between the intensity level of the mass signal and the intensity level of the noise.

The linear dynamic range is described as the range of linearity of the ion signal measured as a function of the analyte concentration. The enormously broad scope of nutritional research e. There are many books describing in great detail various mass spectrometric technologies either from a purely instrumental perspective or from a more applicative viewpoint.

About - JSM Human Nutrition and Food Science - JSMCentral

Below we briefly describe each instrumentation starting with the ionization sources, and then describe the various mass analyzers and ion detection devices commonly available on the market. The hyphenation with different chromatographic systems is covered at the end of the chapter. Any species — be it an organic molecule or an inorganic element — to be analyzed in a mass spectrometer needs to be ionized unless already present in an ionic form.

Both these species have the same mass as the original molecule, with the mass of the electron being negligibly small. The analyte may also be ionized by addition or subtraction of charged species e. Ionization is a key process in mass spectrometry and much instrumental and theoretical work has been devoted to understanding the processes that convert a neutral molecule into an ionized species cation or anion.

This process takes place in the so-called ionization source, which is also responsible for the transfer of the newly produced ions into the gas phase prior to their introduction into the analyzer of the mass spectrometer.

Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research

There are several ionization sources namely:. Electron ionization EI — formerly also called electron impact ionization — is the oldest method of ionization. It originates from the work of J. Thompson — who won the Nobel Prize in physics in for having generated ionized species following a discharge of electricity into gases. Energetic electrons from a heated filament are accelerated by an electric field through the high vacuum ion chamber containing the gaseous sample.

Such energetic electrons will transfer part of their energy to the neutral volatilized analyte, causing an electron to be ejected from the molecule forming a molecular ion through the reaction:. In most electron ionization conditions, only one molecule out of a million will be ionized.

TIER 1 ARTICLE TYPES

The energy of the electron beam is approximately 70 eV; keeping this energy constant between instruments allows standardized spectra to be obtained and the assembly of EI spectra libraries for identification of compounds with so far unknown EI spectra. Most of the organic analytes have an ionization potential i. After participation the participant:. The course consists of lectures, tutorials, computer practical, excursion, and consultation with faculty.


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The course will be held from August The course will start on Monday at 9. Lectures will be given at Wageningen University. Wageningen is located 5 kms from the train station of Ede-Wageningen. This railway station can be reached by train from the airport Schiphol in about one hour.

Webinar: LC-MS-based Metabolomics: Workflows, Strategies and Challenges

Single room 69 euro per night, twin room, single use 74,50 euro per night including breakfast, excluding taxes. Transport to Wageningen Campus by bus public transport or bike to be rent at the hotel. Participants have to book their own room. The final registration date is 12 July